| 魏星旭，蔺晓源，刘杰民，曹龙.溃疡性结肠炎脾肾阳虚证与免疫炎症的关系探讨[J].中医药信息,2025,42(10):1-6 |
| 溃疡性结肠炎脾肾阳虚证与免疫炎症的关系探讨 |
| Exploration of the Relationship Between Spleen－Kidney Yang Deficiency and Immune Inflammation in Ulcerative Colitis |
| 投稿时间：2025-01-03 录用日期：2025-01-23 |
| DOI：10.19656/j.cnki.1002-2406.20251001 |
| 中文关键词: 溃疡性结肠炎 脾肾阳虚证 免疫 炎症 |
| 英文关键词: Ulcerative colitis Spleen－Kidney Yang Deficiency syndrome Immunity Inflammation |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 溃疡性结肠炎（UC）是一种发生在结肠和直肠的特发性慢性复发性炎症性肠病，临证以脾肾阳虚证为主。本文探索UC脾肾阳虚证与免疫炎症的内在联系，总结脾肾与免疫功能的关系，探讨脾肾阳虚致痰湿瘀毒等病理产物与炎症的相关性，旨在进一步阐释脾肾阳虚证候本质在UC中的内涵。结果发现，脾肾阳虚型UC，邪伤肠络，破溃成疡，阳虚水泛，痰湿内停，气阳虚乏，瘀血阻络，阳郁邪蕴，痈毒内生，类似于西医学中渗出性炎症、增生性炎症、变质性炎症；痰湿瘀毒等实邪为患又可伤及阳气，加重脾肾阳虚，致UC进展。因此，临证应以“培补脾肾”为本，驱邪不伤正，使得脾肾互用，痰湿瘀毒之邪得祛。 |
| 英文摘要: |
| Ulcerative colitis （UC） is an idiopathic chronic recurrent inflammatory bowel disease occurring in the colon and rectum， clinically manifesting primarily as Spleen－Kidney Yang Deficiency syndrome. This paper explores the intrinsic relationship between Spleen－Kidney Yang Deficiency syndrome in UC and immune inflammation， summarizes the relationship between the spleen－kidney system and immune function， and investigates the correlation between pathological products such as phlegm－dampness and blood stasis toxins caused by Spleen－Kidney Yang Deficiency and inflammation， aiming to further elucidate the essential connotation of Spleen－Kidney Yang Deficiency syndrome in UC. The results reveal that in Spleen－Kidney Yang Deficiency type UC， pathogenic factors damage intestinal collaterals leading to ulceration， Yang deficiency causes water overflow， phlegm－dampness internally retains， deficiency of Qi and Yang gives rise to this change， blood stasis obstructs collaterals， Yang stagnation causes pathogens accumulation， and endogenous abscess toxins generates. The changes are similar to exudative inflammation， proliferative inflammation， and alterative inflammation in Western medicine. Substantial pathogenic factors like phlegm－dampness and blood stasis toxins can further damage Yang Qi， aggravating Spleen－Kidney Yang Deficiency and promoting UC progression. Therefore， clinical treatment should focus on "tonifying the spleen and kidney" as the fundamental approach， eliminating pathogens without harming healthy Qi， enabling spleen－kidney interaction and removal of phlegm－dampness－blood stasis toxins. |
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