| 王祎甜，孙忻.中医药治疗卵巢储备功能减退的作用机制研究进展[J].中医药信息,2025,42(10):85-89 |
| 中医药治疗卵巢储备功能减退的作用机制研究进展 |
| Research Progress on the Mechanism of Traditional Chinese Medicine in Treating Diminished Ovarian Reserve |
| 投稿时间：2025-03-23 录用日期：2025-04-10 |
| DOI：10.19656/j.cnki.1002-2406.20251016 |
| 中文关键词: 卵巢储备功能减退 中医药 针灸 机制 综述 |
| 英文关键词: Diminished ovarian reserve Traditional Chinese medicine Acupuncture Mechanism Review |
| 基金项目: |
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| 摘要点击次数: 44 |
| 全文下载次数: 25 |
| 中文摘要: |
| 卵巢储备功能减退（DOR）是由于卵母细胞的数量减少和（或）质量下降，导致卵巢功能不足，若未及时干预，则可能发展为卵巢早衰。西医治疗多以激素替代为主，但不良反应较多；中医药在治疗DOR方面表现出良好的临床效果。本文就近年来中医药治疗DOR的相关作用机制进行综述，发现中药复方口服、针灸等方法均能够降低机体氧化应激水平，抑制颗粒细胞自噬、凋亡，减少卵泡闭锁，调节机体免疫环境，改善子宫、卵巢血流微循环，从而改善卵巢储备功能，并且具有疗效优、副作用小、多靶点调节等优势。 |
| 英文摘要: |
| Diminished ovarian reserve （DOR） is characterized by reduced quantity and/or quality of oocytes leading to insufficient ovarian function， which may progress to premature ovarian failure if not promptly intervened. Western medicine primarily employs hormone replacement therapy， but this approach often carries significant adverse effects. Traditional Chinese Medicine （TCM） has demonstrated favorable clinical outcomes in treating DOR. This article reviews recent research on the mechanisms of TCM in DOR treatment， finding that oral administration of Chinese herbal formulas and acupuncture can effectively reduce oxidative stress levels， inhibit granulosa cell autophagy and apoptosis， decrease follicular atresia， modulate immune microenvironment， and improve uterine and ovarian microcirculation. These interventions consequently enhance ovarian reserve function， offering advantages including superior efficacy， minimal side effects， and multi－target regulation. |
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