| 陈永孟，丁立山，马梁浩，王聪梅，邢作英，陈清亮.基于隐结构模型和关联规则分析晚期胃癌治疗的方药规律[J].中医药信息,2025,42(10):46-53 |
| 基于隐结构模型和关联规则分析晚期胃癌治疗的方药规律 |
| Analysis of Formulae Patterns for Advanced Gastric Cancer Treatment Based on Latent Structure Model and Association Rules |
| 投稿时间：2025-03-30 录用日期：2025-04-16 |
| DOI：10.19656/j.cnki.1002-2406.20251009 |
| 中文关键词: 晚期胃癌 隐结构 关联规则 用药规律 |
| 英文关键词: Advanced gastric cancer Latent structure Association rules Medication patterns |
| 基金项目:国家自然科学基金委员会青年科学：81803944；河南省医学科技攻关计划联合共建项目：LHGJ20240648；郑州市医疗卫生领域科技创新指导计划项目：2024YLZDJH056 |
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| 中文摘要: |
| 目的：基于隐结构模型和关联规则的方法探究晚期胃癌治疗的方药规律，为临床辨证论治晚期胃癌及指南的制定提供理论支撑。方法：系统性检索中国知网（CNKI）、万方（Wanfang）、维普（VIP）、中国生物医学文献数据库（SinoMed），筛选方药治疗晚期胃癌的相关文献并提取资料；运用Microsoft Excel 2019建立数据库，通过Lantern 5.0及Rstudio软件对频率 > 4%的中药进行隐结构模型与关联规则分析，结合频数结构模型，总结晚期胃癌的方药规律。结果：最终纳入中医处方217首，涉及单味中药218味，中药累计使用频次2 555次，高频中药为白术、茯苓、黄芪、党参等，功效以补虚药为主。隐结构分析共获得14个隐变量、28个隐类、6个综合聚类模型、15个核心方剂，以方测证推断出晚期胃癌以脾虚湿盛、脾胃虚寒、胃阴不足、脾虚食滞、肝胃不和和瘀毒内阻为常见证型。关联规则分析获取46条强关联规则，支持度最高为茯苓－白术，置信度最高为党参－茯苓－黄芪－陈皮－白术。结论：晚期胃癌为本虚标实之证，核心病机为“虚”“滞”“瘀”，与脾、肺、胃三脏关系密切，治疗当以健脾和胃、扶正祛邪为原则，随证应使用调理脏腑阴阳、调达气机、清热化瘀等治疗方法。 |
| 英文摘要: |
| Objective： To explore Formulae patterns for advanced gastric cancer （AGC） treatment using latent structure model and association rules， providing theoretical support for clinical syndrome differentiation and guideline development. Methods： Systematic searches were conducted in CNKI， Wanfang， VIP， and SinoMed databases to identify and select literature on herbal Formulas for AGC. A database was established using Microsoft Excel 2019. Herbs with frequency > 4% were analyzed through latent structure modeling （Lantern 5.0） and association rules （Rstudio）， combined with frequency structure model to summarize formulae patterns. Results： 217 formulaes involving 218 single herbs （2 555 total applications） were included. High frequency herbs included Atractylodis Macrocephalae Rhizoma， Poria， Astragali Radix， and Codonopsis Radix， primarily tonifying deficiency herbs. Latent structure analysis identified 14 latent variables， 28 latent classes， 6 comprehensive clustering models， and 15 core formulas， revealing common AGC syndromes： spleen deficiency with dampness accumulation， spleen stomach deficiency cold， stomach yin deficiency， spleen deficiency with food stagnation， liver stomach disharmony， and blood stasis toxin accumulation. Association rules yielded 46 strong correlations， with highest support for Poria Atractylodis Macrocephalae Rhizoma and highest confidence for Codonopsis Radix Poria Astragali Radix Citri Reticulatae Pericarpium-Atractylodis Macrocephalae Rhizoma. Conclusion： AGC manifests as deficiency excess complex with core pathogenesis of "deficiency"， "stagnation" and "stasis" closely related to spleen， lung and stomach. Treatment should prioritize spleen stomach fortification and strengthening healthy qi while eliminating pathogens， supplemented by syndrome－specific approaches including organ regulation， qi rectification， heat clearing， and stasis resolving therapies. |
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