| 夏云，王伊池，曹徵良，王慧娟，阳艳，林珏，汤伟，娄必丹.基于“心脑同治”探讨针刺对脑瘫智力障碍患儿的疗效及其对血清S100β、NSE的影响[J].中医药信息,2025,42(10):54-58 |
| 基于“心脑同治”探讨针刺对脑瘫智力障碍患儿的疗效及其对血清S100β、NSE的影响 |
| Exploring the Efficacy of Acupuncture in Children with Cerebral Palsy and Intellectual Disability Based on "Simultaneous Treatment of Heart and Brain" and Its Effects on Serum S100β and NSE |
| 投稿时间：2025-06-16 录用日期：2025-06-25 |
| DOI：10.19656/j.cnki.1002-2406.20251010 |
| 中文关键词: 脑瘫 智力障碍 心脑同治 针刺 NSE S100β |
| 英文关键词: Cerebral palsy Intellectual disability Simultaneous treatment of heart and brain Acupuncture NSE S100β |
| 基金项目:湖南省卫生健康委科研项目（202206044422） |
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| 中文摘要: |
| 目的：观察“心脑同治”针刺治疗结合认知功能训练对脑瘫智力障碍患儿的疗效及其对血清S100β、NSE的影响。方法：选择湖南中医药大学第一附属医院收治的符合纳入标准的脑瘫智力障碍患儿40例，依据随机数字表随机分为观察组和对照组，每组各20例。在常规基础治疗的基础上，对照组接受认知功能训练，观察组在对照组的基础上予以“心脑同治”针刺治疗，治疗频率为每日1次，每周进行5次，每4周为1个周期，连续治疗3个周期。比较两组患儿治疗前后儿心量表、日常生活活动能力（ADL）量表评分，以及血清S100β、NSE含量变化情况。结果：与治疗前比较，治疗后两组患儿DQ评分、ADL评分较治疗前均明显提高，差异具有统计学意义（P < 0.05）。治疗后，观察组患儿DQ、ADL评分均显著高于对照组，差异具有统计学意义（P < 0.05）。两组患儿治疗后血清S100β和NSE含量均显著低于治疗前（P < 0.05），且观察组患儿的血清S100β和NSE含量显著低于对照组（P < 0.05）。结论：“心脑同治”针刺治疗联合认知功能训练可有效提升脑瘫智力障碍患儿的认知能力，增强日常生活活动能力，降低血清NSE、S100β水平。 |
| 英文摘要: |
| Objective： To observe the efficacy of "simultaneous treatment of heart and brain" acupuncture treatment combined with cognitive function training in children with cerebral palsy and intellectual disability and its effects on serum S100β and NSE. Methods： Forty children with cerebral palsy and intellectual disability （met the inclusion criteria） treated at The First Affiliated Hospital of Hunan University of Chinese Medicine were selected and randomly divided into an observation group and a control group using a random number table， with 20 cases in each group. On the basis of conventional basic treatment， the control group received cognitive function training， while the observation group received "simultaneous treatment of heart and brain" acupuncture in addition to the control group's treatment. The treatment frequency was once daily， 5 times per week， with every 4 weeks as one cycle， for a total of 3 consecutive cycles. The developmental quotient （DQ） scores， activities of daily living （ADL） scale scores， and changes in serum S100β and NSE levels were compared between the two groups before and after treatment. Results： Compared with before treatment， the DQ scores and ADL scores of both groups were significantly improved after treatment， with statistically significant differences （P < 0.05）. After treatment， the DQ and ADL scores of the observation group were significantly higher than those of the control group， with statistically significant differences （P < 0.05）. The serum S100β and NSE levels of both groups after treatment were significantly lower than those before treatment （P < 0.05）， and the serum S100β and NSE levels of the observation group were significantly lower than those of the control group （P < 0.05）. Conclusion： "Simultaneous treatment of heart and brain" acupuncture treatment combined with cognitive function training can effectively improve cognitive ability and enhance activities of daily living in children with cerebral palsy and intellectual disability， while reducing serum NSE and S100β levels. |
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