| 乌日汉,陈玉花,肖田梅,毕力格,丽丽,孟香花,宝乐尔,韩晓静,白梅荣.诃子对川楝子所致肝毒性的减毒作用机理初探[J].中医药信息,0,(): |
| 诃子对川楝子所致肝毒性的减毒作用机理初探 |
| Preliminary study on the mechanism of reducing hepatotoxicity of Terminalia chebula to Toosendan fruit |
| 投稿时间：2021-05-31 录用日期：2021-07-02 |
| DOI： |
| 中文关键词: 诃子 川楝子 肝毒性 减毒作用 机理初探 |
| 英文关键词: STerminalia chebula toosendan fruit hepatotoxicity attenuated role Preliminary study on the mechanism |
| 基金项目:蒙药安全性评价创新团队项目(MY20190003);国家民委-教育部蒙医药研发重点实验室开放课题(MDK2019063).中央支持地方建设专项资金交叉学科建设项目(JCHXKXM001). |
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| 中文摘要: |
| 目的：初步探讨诃子缓解川楝子致肝毒性作用机制。方法：以含有诃子和川楝子药味的复方三子汤及拆方后诃子、川楝子、栀子、川楝子加诃子、川楝子加栀子、诃子加栀子药对为示例药物,以SD大鼠为研究对象,除正常组外各给药组灌胃相应的药物溶液,连续给药21d,观察其各给药组对肝功能和病理形态学的影响,采用血清代谢组学的方法对大鼠血清代谢轮廓进行分析,筛选各组指标性生物标示物。结果：与正常组比较,川楝子组血清ALT、AST含量显著升高 (P＜0.05),其他组血清ALT、AST含量无升高趋势；肝组织HE染色结果表明,除了川楝子组有少量的肝细胞肿胀、川楝子加诃子组肝细胞胞质疏松淡染外,三子汤和诃子组肝细胞无明显异常变化；代谢组学分析结果显示,川楝子组血清样本中与肝毒性相关的溶血磷脂酰胆碱、缬氨酸和吡咯-2-羧酸明显升高；但诃子、川楝子加诃子和三子汤组中差异代谢物含量低于川楝子组,且明显向正常水平回调。结论：诃子可降低川楝子的肝毒性,其解毒机制可能与降低血清溶血磷脂酰胆碱18：2含量有关。诃子具有配伍减毒作用。 |
| 英文摘要: |
| Objective Preliminary study on the mechanism of terminalia chebula palliating hepatotoxicity induced by toosendan fruit.Methods Use the compound Sanzitang containing the medicinal flavor of Terminalia chebula and toosendan fruit, and the drug pairs of Terminalia chebula, toosendan fruit, gardenia,toosendan fruit plus terminalia chebula , toosendan fruit plus gardenia,terminalia chebula plus gardenia as an example drug, rats as the research objects, except for the normal group, each administration group was given corresponding solution continuous administration for 21 days,observe the effect of each administration group on liver function and pathomorphology,and metabolic profile of the serum samples of rats were detected by the method of serum metabolomics.Indicative biomarkers were screened in each group. Results Compared with the normal group, the content of ALT and AST could be remarkably improved by fuetus toosendan(P < 0.05),and serum ALT、AST content in other groups was not increased.HE staining showed that there was no abnormal change in the liver cells of Sanzitang and terminalia chebula |
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