文章摘要
费晓影,王思农,王亚红,李丹.藏药二十五味儿茶凝胶对慢性湿疹模型大鼠血清中CCL17及CCL18表达的影响[J].中医药信息,0,():
藏药二十五味儿茶凝胶对慢性湿疹模型大鼠血清中CCL17及CCL18表达的影响
Effect of Tibetan Medicine 25 Flavor Catechu Gel on Expression of CCL17 and CCL18 in Serum of Rats with Chronic Eczema
投稿时间:2021-07-26  录用日期:2021-09-02
DOI:
中文关键词: 慢性湿疹,藏药二十五味儿茶凝胶,CCL17,CCL18
英文关键词: chronic  eczema, Tibetan  medicine 25 catechu  gel, CCL17, CCL18
基金项目:西北中藏药协同中心重点项目( XBXT2015-3)
作者单位E-mail
费晓影 甘肃中医药大学 3375609238@qq.com 
王思农* 甘肃中医药大学 15095319507@163.com 
王亚红 甘肃中医药大学 甘肃兰州 730000  
李丹 甘肃中医药大学 甘肃兰州 730000  
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中文摘要:
      目的 藏药二十五味儿茶凝胶对慢性湿疹大鼠血清中CCL17及CCL18的作用。方法 采用2,4-二硝基氯苯(DNCB)诱导大鼠背部慢性湿疹。将60只SD大鼠随机分为6组,即空白组、模型组、对照组、藏药二十五味儿茶凝胶高、中、低剂量组6组。对照组给予青鹏软膏外用涂抹,藏药二十五味儿茶凝胶低(0.0025g/cm2/d)、中(0.005g/g/cm2/d)、高(0.01g/g/cm2/d)剂量涂抹给药,肉眼观察大鼠背部慢性湿疹皮损程度并进行评分,采用ELISA法检测大鼠血清中趋化因子CCL17和CCL18水平。结果 藏药二十五味儿茶凝胶能够有效减轻大鼠背部慢性湿疹的皮损程度,治疗组干预后血清中CCL17和CCL18水平均下降。结论 藏药二十五味儿茶凝胶能够有效改善湿疹模型大鼠背部皮损,可能与下调慢性湿疹大鼠模型趋化因子CCL17及CCL18血清水平有关。
英文摘要:
      Objective To investigate the effects of Tibetan medicine 25 catechu gel on serum CCL17 and CCL18 in chronic eczema rats. Methods 2, 4-dinitrochlorobenzene (DNCB) was used to induce chronic dorsal eczema in rats. Sixty SD rats were randomly divided into 6 groups: blank group, model group, control group, Tibetan medicine 25flavour catechu gel high-dose, medium-dose and low-dose groups. The control group was given external daub of Qingpeng ointment, and the Tibetan medicine 25 Acetechu Gel was daubed at low (0.0025g/cm2/d), medium (0.005g/g/cm2/d) and high (0.01g/g/cm2/d) doses. The lesions of chronic eczema on the back of rats were observed by naked eyes and scored. Serum chemokines CCL17 and CCL18 were detected by ELISA. Results The CCL17 and CCL18 levels in serum of the treatment group were decreased after intervention. Conclusion The Tibetan medicine 25 kinds of catechu gel can effectively improve the back lesions of rats with eczema, which may be related to the down-regulation of serum levels of chemokine CCL17 and CCL18 in rats with chronic eczema.
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