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| 枳实薤白桂枝汤治疗寒凝痰瘀气滞证素不稳定型心绞痛的临床研究 |
| Clinical study of Zhishi Xiebai Guizhi Decoction in the treatment of unstable angina pectoris |
| 投稿时间：2020-03-15 录用日期：2020-05-19 |
| DOI： |
| 中文关键词: 枳实薤白桂枝汤 证素 不稳定型心绞痛 纤维蛋白原 D-二聚体 |
| 英文关键词: Zhishi Xiebai Guizhi Decoction syndrome element unstable angina pectoris fibrinogen D-dimer |
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| 中文摘要: |
| 目的：临床观察枳实薤白桂枝汤治疗寒凝痰瘀气滞证素不稳定型心绞痛(UA)的效果及对纤维蛋白原(FIB)、D-二聚体(D-D)水平的影响。方法：将62例寒凝痰瘀气滞证素UA患者随机分成对照组和治疗组,对照组30例,治疗组32例。对照组采用西医常规治疗方案,治疗组在对照组治疗方案的基础上加用枳实薤白桂枝汤。两组疗程均为2周。比较两组患者治疗前后的中医证候疗效、心电图、FIB、D-D的变化。结果：两组中医证候疗效,治疗组总有效率84.4%,对照组60.0%,有统计差异(P＜0.05)；两组显效率,治疗组显效率40.6%,对照组显效率16.7%,亦有统计差异(P＜0.05)。心电图疗效,治疗组总有效率为50.0%,对照组为43.3%,无统计差异(P＞0.05)；但治疗组对ST段压低的治疗效果优于对照组(P＜0.05),治疗组对该项心电图改变的总有效率65.2%,对照组总有效率35.0%。治疗前两组的FIB、D-D水平无统计差异(P＞0.05)。治疗后两组FIB、D-D水平均下降明显(P＜0.05,P＜0.01)；治疗后,两组间FIB水平比较,差异具有统计学意义(P＜0.05),两组间D-D水平比较,差异无统计学意义(P＞0.05)。结论：枳实薤白桂枝汤能够改善UA患者的临床症状,降低FIB和D-D水平。 |
| 英文摘要: |
| Objective: To observe the clinical effect of Zhishi xiebaijiezhi Decoction on unstable angina pectoris (UA) with syndrome of cold coagulation, phlegm stasis and qi stagnation and its effect on fibrinogen (FIB) and D-Dimer (D-D) levels. Methods: 62 cases of UA with cold coagulation, phlegm stasis and qi stagnation syndrome were randomly divided into control group and treatment group, 30 cases in control group and 32 cases in treatment group. The control group was treated with conventional western medicine, and the treatment group was treated with Zhishi xiebaiquizhi Decoction on the basis of the control group. The course of treatment in both groups was 2 weeks. The therapeutic effect, ECG, FIB and D-D of the two groups were compared before and after treatment. Results: the total effective rate of the two groups was 84.4% in the treatment group and 60.0% in the control group, with statistical difference (P < 0.05); the effective rate of the two groups was 40.6% in the treatment group and 16.7% in the control group, with statistical difference (P < 0.05). The total effective rate of ECG was 50.0% in the treatment group and 43.3% in the control group, with no statistical difference (P > 0.05). However, the therapeutic effect of ST segment depression in the treatment group was better than that in the control group (P < 0.05). The total effective rate of ECG change in the treatment group was 65.2% and 35.0% in the control group. There was no statistical difference in FIB and D-D levels between the two groups before treatment (P > 0.05). After treatment, FIB and D-D water in the two groups decreased significantly (P < 0.05, P < 0.01); after treatment, FIB levels between the two groups were statistically significant (P < 0.05), and there was no statistically significant difference between the two groups (P > 0.05). Conclusion: Zhishi xiebaiquizhi decoction can improve the clinical symptoms of UA patients and reduce the levels of FIB and d-d. |
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