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| 五倍子、儿茶和黄连对130株艰难梭菌的体外抗菌活性研究 |
| Observation of Antibacterial Activity of 3 kinds of Traditional Chinese Medicine against 130 Strains of Clostridium difficile in vitro |
| 投稿时间：2020-03-17 录用日期：2020-04-22 |
| DOI： |
| 中文关键词: 五倍子 儿茶 黄连 艰难梭菌 抗菌活性 |
| 英文关键词: Galla chinensis catechu coptis chinensis Clostridium difficile Antibacterial activity. |
| 基金项目:河北省中医药管理局科研计划项目(2018122)；河北省科技厅国际合作项目(183977118D) |
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| 中文摘要: |
| 目的 观察五倍子、儿茶和黄连3味中药对艰难梭菌的体外抗菌活性。方法 采用琼脂稀释法测定五倍子、儿茶和黄连对130株艰难梭菌的最低抑菌浓度。结果 五倍子、儿茶和黄连对130株艰难梭菌均有一定的抗菌活性, 其中以五倍子对艰难梭菌的抗菌活性最强, 其MIC50和MIC90分别为0.104mg/ml和0.225mg/ml。儿茶的MIC50和MIC90分别为10.215mg/ml和12.191mg/ml。结论 五倍子、儿茶和黄连这3味中药对艰难梭菌有抗菌作用。五倍子对CD的抗菌活性最强,其次是儿茶,最弱是黄连。研究证明中药具有治疗艰难梭菌感染的潜在价值。 |
| 英文摘要: |
| Objective: This study was aimed to evaluate the antibacterial activity of galla chinensis, catechu and coptis chinensis against 130 strains of Clostridium difficile in vitro. Methods: The minimum inhibitory concentration (MIC)of 3 kinds of traditional Chinese medicine against the 130 strains of Clostridium difficile was determined by agar dilution method. Results: The antibacterial activity of galla chinensis against 130 Clostridium difficile strains was remarkable, the MIC50 as well as the MIC90 were 0.104mg/ml and 0.225mg/ml respectively. The MIC50 and the MIC90 of catechu were 10.215 mg/ml and 12.191mg/ml respectively. Coptis chinensis showed the weakest antibacterial activity. Conclusion: Galla chinensis,catechu and coptis chinensis had different antibacterial activity against Clostridium difficiles. The results of this study provided a alternative prospect of anti-infective Chinese herbal drugs in Clostridium difficiles infection treatment. |
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