| Objective To observe the effect of Lianyu Xiaoying Decoction on TREM2 in peripheral blood of patients with Hashimoto thyroiditis with normal thyroid function and its clinical significance. Methods 132 hashimoto thyroid patients with normal thyroid function who were admitted to the endocrinology department of our hospital from January 2017 to July 2019 were selected.All 132 HT patients were divided into Lianyu Xiaoying herbal group, Selenious yeast western medicine group and the group of herbs and western medicine by randomized, controlled, parallel experimental design method.Treatment after 12 weeks, the concentration of FT3,FT4,TSH,TPO-Ab and TG-Ab were detected by chemiluminescence immunoassay,the expression level of IL-17,IFN-γwere determined by enzyme-linked immunosorbent assay (ELISA) , the level of TREM2 in the PBMC was determined by flow cytometry. Results Comparison before and after treatment: TPO-Ab and TG-Ab in the three groups of combined group, decoction group and western medicine group were lower than those before treatment (P <0.05), and IL-17 and IFN-γ of combined group and decoction group were lower than those before treatment (P <0.05), the proportion of PBMC in the combination group and the decoction group was higher than that before treatment (P <0.05); comparison between the groups after treatment: the levels of TPO-Ab, TG-Ab, serum IL-17, IFN-γ in the combination group were significantly lower than those in the decoction group and western medicine group (P <0.05);TPO-Ab, TG-Ab, serum IL-17, IFN-γ levels in the decoction group were lower than those in the western medicine group (P <0.05); the proportion of TREM2 in the combination group was significantly higher than that in the decoction group, western medicine group (P <0.05), the proportion of TREM2 in PBMC of decoction group was higher than that of western medicine group (P <0.05).Conclusion Lianyu Xiaoying Decoction could notably decrease the titer of TPO-Ab and TG-Ab ,the level of serum IL-17,IFN-γ,and increases the proportion of TREM2 in PBMC of patients with Hashimoto thyroiditis with normal thyroid function, regulate the body's immune function and improve Hashimoto thyroiditis. |
