文章摘要
基于网络药理学探讨山药治疗糖尿病心肌病的作用机制
Discussion on Mechanism of Dioscoreae Rhizoma on Diabetic Cardiomyopathy Based on Network Pharmacologyish
投稿时间:2020-07-15  录用日期:2020-08-15
DOI:
中文关键词: 网络药理学  糖尿病心肌病  山药  薯蓣皂苷元  靶点  作用机制
英文关键词: network pharmacology  diabetic cardiomyopathy  yam  diosgenin  target  mechanism of action
基金项目:国家自然青年科学基金项目;黑龙江省中医药管理局项目;黑龙江中医药大学教育教学研究项目
作者单位邮编
黄楠楠 黑龙江中医药大学药学院 150040
王锴华 黑龙江中医药大学药学院 150040
陈珊 黑龙江中医药大学药学院 150040
孙爽 黑龙江中医药大学药学院 150040
杨德强 黑龙江中医药大学药学院 150040
张春晶 黑龙江中医药大学药学院 150040
都晓伟* 黑龙江中医药大学药学院 150040
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中文摘要:
      目的:探讨山药治疗糖尿病心肌病的作用机制。方法:在TCMSP数据库中寻找山药的活性成分,并对其进行靶点预测;在疾病数据库检索糖尿病心肌病(DCM)的靶点;利用Venn图得到山药和DCM的共同靶点;使用Cytoscape软件绘制“山药-活性成分-疾病-靶点”网络图;在STRING数据库中进行蛋白互作分析(PPI);利用DAVDI数据库进行KEGG通路分析和GO生物功能注释。结果:发现了符合标准的16个活性物质和69和作用靶点,主要涉及ADRB2,ADRB1,NOS3等。在DAVID的数据库分析中,获得了63个主要通路和130条GO生物功能注释。结论:山药可能通过多种成分、多个靶点、多条通路的来治疗糖尿病心肌病,其作用机理可能是通过主要活性成分(-)-花旗松素和薯蓣皂苷元与cGMP-PKG通路和氧化还原酶活性、凋亡过程的负调控等过程来诱导高糖环境下的心肌细胞凋亡来防止心肌细胞肥大,从而治疗糖尿病心肌病。
英文摘要:
      Objective: To explore the mechanism of yam in treating diabetic cardiomyopathy. Methods: Find the active ingredients of yam in TCMSP database and predict its target; search the target of diabetic cardiomyopathy (DCM) in disease database; use the Venn diagram to get the common target of yam and DCM; use Cytoscape software to draw "Yam-active ingredient-disease-target" network diagram; protein interaction analysis (PPI) in STRING database; KEGG pathway analysis and GO biological function annotation using DAVDI database. Results: 16 active substances and 69 target targets were found, which mainly involved ADRB2, ADRB1, NOS3, etc. In DAVID""s database analysis, 63 main pathways and 130 GO biological function annotations were obtained. Conclusion: Yam may be used to treat diabetic cardiomyopathy through multiple ingredients, multiple targets, and multiple pathways. The mechanism of action may be through the main active ingredients (-)-taxifolin and Diosgenin and cGMP-PKG pathway and Processes such as oxidoreductase activity and negative regulation of the apoptosis process induce cardiomyocyte apoptosis in a high-sugar environment to prevent cardiomyocyte hypertrophy, thereby treating diabetic cardiomyopathy.
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