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| 针刺轻度认知障碍患者太溪穴任务态功能磁共振成像研究 |
| Task state fMRI study of acupuncture at Taixi point in patients with mild cognitive impairment |
| 投稿时间：2021-02-22 录用日期：2021-03-16 |
| DOI： |
| 中文关键词: 针刺 任务态 功能磁共振成像 轻度认知障碍 太溪穴 |
| 英文关键词: Acupuncture Task state：fMRI mild cognitive impairment Taixi point |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 摘要：目的 基于任务态功能磁共振成像技术，通过观察轻度认知障碍（MCI）患者太溪穴针刺态脑神经元活动的改变，探讨针刺对认知相关脑区的神经调节机制。方法 选择轻度认知障碍患者16例，采用16分钟任务态实验设计。使用3.0 T磁共振扫描仪，首先采集8分钟基线静息态数据，再采集8分钟针刺太溪穴的针刺态数据。数据经后处理与一般线性模型分析，基于体素水平P=0.001(未校正)和cluster水平P＜0.05（FWE校正），获得MCI患者针刺态脑内神经元活动改变的脑功能区。结果 针刺MCI患者右侧太溪穴正激活脑区为左侧眶部额下回（BA47）、右侧三角部额下回（BA45）、左侧岛盖部额下回（BA44）、右侧岛叶（BA13）、左侧颞上回（BA38）、右侧颞下回（BA20）、右侧小脑前叶、后叶、右侧丘脑。负激活脑区为左侧后扣带回（BA31）、左侧楔前叶（BA7）、右侧海马回。结论 针刺MCI患者太溪穴的即刻效应可直接影响认知活动相关脑区的神经元活动，调节病理性失衡的认知回路，可能是针灸对MCI治疗的潜在神经机制。 |
| 英文摘要: |
| Abstract: Objective：To investigate the neural regulatory mechanism of acupuncture on cognitive related brain regions by observing the changes of neuronal activity in Taixi acupoint of mild cognitive impairment (MCI) patients based on task state functional magnetic resonance imaging (fMRI). Methods：Sixteen patients with mild cognitive impairment were enrolled in this study. Using 3.0 T magnetic resonance scanner, the baseline resting state data of 8 minutes were collected, and then the acupuncture state data of acupuncture at Taixi point for 8 minutes were collected. The data were analyzed by post-processing and general linear model. Based on voxel level P = 0.001 (uncorrected) and cluster level P < 0.05 (fwe correction), the functional areas of brain neurons in MCI patients with acupuncture state were obtained. Results：The positive activation areas of right Taixi in MCI patients were left inferior frontal gyrus (BA47), right inferior frontal gyrus (BA45), inferior frontal gyrus (BA44), right insular (BA13), left superior temporal gyrus (BA38), right inferior temporal gyrus (BA20), right anterior cerebellar lobe, posterior lobe and right thalamus. The negative activation areas were left posterior cingulate gyrus (BA31), left precuneus lobe (BA7) and right hippocampal gyrus. Conclusion：The immediate effect of acupuncture at Taixi point in MCI patients can directly affect the neuronal activities in the brain regions related to cognitive activities, and regulate the cognitive circuit of pathological imbalance, which may be the potential neural mechanism of acupuncture for MCI treatment. |
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