| 李阳;孙亚飞;王振.四君子汤加味对直肠癌术后患者血清肿瘤标志物及免疫应激反应的影响[J].中医药信息,2023,40(8):65-69 |
| 四君子汤加味对直肠癌术后患者血清肿瘤标志物及免疫应激反应的影响 |
| Effects of Modified Sijunzi Decoction on Serum Tumor Markers and Immune Stress Response in Patients with Postoperative Rectal Cancer |
| 投稿时间：2022-09-22 录用日期：2022-11-15 |
| DOI：10.19656/j.cnki.1002-2406.20230810 |
| 中文关键词: 四君子汤加味 直肠癌术 肿瘤标志物 免疫应激反应 |
| 英文关键词: Modified Sijunzi Decoction Rectal cancer surgery Tumor markers Immune stress response |
| 基金项目: |
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| 摘要点击次数: 126 |
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| 中文摘要: |
| 目的：探究四君子汤加味对直肠癌术后患者血清肿瘤标志物及免疫应激反应的影响。方法：选取驻马店市中心医院收治符合纳入标准的130例直肠癌术后患者，通过随机抛硬币法将患者分为对照组和观察组，对照组57例采取常规肠内营养支持治疗，观察组73例在对照组基础上使用四君子汤加味治疗，两组均连续治疗1个月。比较两组患者治疗前后肿瘤标志物[癌胚抗原（carcinoembryonic antigen,CEA）、糖类抗原199(carbohydrate antigen 199,CA199）、糖类抗原724(carbohydrate antigen 724,CA724]，免疫球蛋白[免疫球蛋白A(immunoglobulin A,IgA）、免疫球蛋白M(immunoglobulin M,IgM）、免疫球蛋白G(immunoglobulin G,IgG）]，应激反应[超氧化物歧化酶（Superoxide dismutase,SOD）、皮质醇（cortisol,Cor）]，胃肠激素[胃泌素（Gastrin,GAS）、胃动素（motilin,mlT）、胃促生长素（Ghrelin）]水平差异及胃肠功能恢复情况。结果：观察组肠鸣音恢复时间、肛门首次排气时间、首次排便时间显著低于对照组（P<0.01）。治疗后，两组患者CEA、CA199、CA724水平均较治疗前下降（P<0.05），且观察组CEA、CA199、CA724水平低于对照组（P<0.01）；两组患者IgA、IgM、IgG水平均较治疗前升高（P<0.05），且观察组IgA、IgM、IgG水平高于对照组（P<0.01）；两组患者SOD水平均较治疗前下降（P<0.05），且观察组SOD水平高于对照组（P<0.01），两组Cor水平均较治疗前升高（P<0.05），且观察组低于对照组（P<0.01）；两组患者GAS、mlT、Ghrelin水平均升高（P<0.05），且观察组高于对照组（P<0.01）。结论：四君子汤加味能够有效降低直肠癌术后患者肿瘤标志物水平，提升免疫力、减轻应激反应、改善胃肠激素水平。 |
| 英文摘要: |
| Objective: To explore the effect of modified Sijunzi Decoction on serum tumor markers and immune stress response in patients with postoperative rectal cancer. Methods: 130 patients who underwent rectal cancer surgery were randomly divided into the control group(n = 57) and the observation group(n =73) by coin toss method. The control group was treated with conventional internal nutrition support; on which basis, the observation group was also treated with modified Sijunzi Decoction. Both groups were treated continuously for 1 month. The level difference of the tumor markers [carcinoembryonic antigen(CEA), carbohydrate antigen 199(CA199), carbohydrate antigen 724(CA724)], immunoglobulin [immunoglobulin A(IgA), immunoglobulin M(IgM), immunoglobulin G(IgG)], stress response [superoxide dismutase(SOD), cortisol(Cor)], gastrointestinal hormones [gastrin(GAS), motilin(mlT), ghrelin(Ghrelin) were compared before and after the treatment in the two groups. The gastrointestinal function recovery was compared between the two groups. Results: The recovery time of bowel sounds, the first anal exhaust time, and the first defecation time were significantly lower in the observation group than those in the control group(P < 0. 05). The levels of CEA, CA199 and CA724 were lower after the treatment than those before the treatment(P < 0. 05), and the levels of CEA, CA199 and CA724 were lower in the observation group than those in the control group(P < 0. 01). The levels of IgA, IgM and IgG were higher after the treatment than those before the treatment in the two groups(P < 0. 05), and the levels of IgA, IgM and IgG were higher in the observation group than those in the control group(P < 0. 05). The level of SOD was decreased after the treatment compared with that before the treatment in the two groups(P < 0. 05), and the level of SOD was higher in the observation group than that in the control group(P < 0. 01). The level of Cor was increased after the treatment compared with that before the treatment in the two groups(P < 0. 05), and the level of SOD was lower in the observation group than that in the control group(P < 0. 01). The levels of GAS, mlT and Ghrelin were increased after the treatment in the two groups(P < 0. 05), of which the observation group was higher than the control group(P < 0. 01). Conclusion: Modified Sijunzi Decoction can effectively reduce the level of tumor markers, enhance immunity, reduce the stress response, and improve the levels of gastrointestinal hormones in treatment of postoperative patients with rectal cancer. |
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