| 陈景云;巩婷;李妍怡;苟梅丽;张静;惠渊;周学锐.自噬在卒中后抑郁中的作用及中药干预机制的研究进展[J].中医药信息,2023,40(9):82-89 |
| 自噬在卒中后抑郁中的作用及中药干预机制的研究进展 |
| Study on the Role of Autophagy in Post－Stroke Depression and the Intervention Mechanism of Traditional Chinese Medicine |
| 投稿时间：2022-10-14 录用日期：2022-11-09 |
| DOI：10.19656/j.cnki.1002-2406.20230914 |
| 中文关键词: 卒中后抑郁 自噬 作用机制 中医药 |
| 英文关键词: Post－stroke depression Autophagy Mechanism of action Traditional Chinese medicine |
| 基金项目:重大疾病中西医联合攻关项目(20210140304)；李妍怡教授从肺脾相用论治原发性多汗症经验总结(2021CXZX-760)；甘肃省自然科学基金(21JR7RA589)。 ,巩婷2△,李妍怡2,苟梅丽2,张静2,惠渊2,周学锐2 |
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| 中文摘要: |
| 卒中后抑郁（PSD）是发生在脑卒中后的一种并发症，具有很高的致残率及致死率，其发病机制尚不明确，但多与炎症反应、氧化应激及细胞凋亡有关。脑源性神经因子（BDNF-TrkB）及哺乳动物雷帕霉素靶蛋白（mTOR）等信号通路介导了PSD的发生与发展，其机制复杂，目前临床缺乏有效的防治措施，而中医药治疗PSD具有多效、多靶点的疗效优势。自噬主要是通过自身的降解和重吸收，维持组织的内稳态的动态平衡，这种作用与中医理论中的阴阳理论较为相似，且PSD的病程进展与自噬密切相关，通过自噬调控进行靶向治疗成为目前PSD中医药治疗的研究热点。 |
| 英文摘要: |
| Post-stroke depression(PSD) is a serious complication that occurs after stroke, with a high disability rate and fatality rate, and has a serious impact on the family and society. The pathogenesis of PSD remains unclear, but it is mostly related to inflammatory response, oxidative stress and apoptosis. Signal pathways, such as brain-derived neural factor and its high-affinity receptor, tropomyosin related kinase B(BDNF-TRKB) and mammalian target of rapamycin(mTOR), mediate the occurrence and development of PSD. The mechanism of the pathways is complex, and effective prevention and treatment measures are lacking at present time. Autophagy mainly maintains the dynamic balance of tissue homeostasis through its own degradation and reabsorption. At present, traditional Chinese medicine(TCM) has the advantage of multi-effect and multi-target efficacy in the treatment of PSD. Scholars have found that autophagy is similar to the theory of yin and yang in TCM, and the disease progression of PSD is closely related to autophagy.Targeted therapy through autophagy regulation has become a research hotspot of TCM treatment of PSD. In this paper, the role of autophagy in PSD and the intervention research of TCM are sorted out and summarized in order to provide new ideas for the development of new drugs and its treatment for PSD. |
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