| 王瑞杰;王钢;张丽.TLR4/MyD88/NF-κB信号通路在RA中的作用及中药干预研究进展[J].中医药信息,2023,40(8):84-89 |
| TLR4/MyD88/NF-κB信号通路在RA中的作用及中药干预研究进展 |
| Role of TLR4/MyD88/NF－κB Signaling Pathway in RA and Research Progress in Chinese Medicinal Intervention |
| 投稿时间：2022-12-08 录用日期：2023-01-11 |
| DOI：10.19656/j.cnki.1002-2406.20230813 |
| 中文关键词: 中药 TLR4/MyD88/NF－κB信号通路 类风湿关节炎 |
| 英文关键词: Chinese medicinal TLR4/MyD88/NF－κB signaling pathway RA |
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| 中文摘要: |
| TLR4/MyD88/NF-κB作为机体炎症的重要信号通路，参与许多疾病的发生与调控过程。类风湿关节炎（RA）是一种慢性自身免疫性疾病，发病机制尚不完全明确，但诸多研究表明，TLRs、NF-κB等炎症信号通路在RA的发生、发展中起着重要的作用，另有研究表明中药可通过影响TLRs、MyD88、NF-κB等信号通路起到调节免疫、调节细胞因子的作用。因此，拟通过分析TLR4/MyD88/NF-κB信号通路在RA发生、发展中的作用，初步探讨中医药通过TLR4/MyD88/NF-κB信号通路治疗RA的研究现状及作用机理，为RA的治疗提供更多的治疗途径。 |
| 英文摘要: |
| As an important signaling pathway for inflammation, TLR4/MyD88/NF-κB participates in the occurrence and regulation of many diseases. Rheumatoid arthritis(RA) is a chronic autoimmune disease, the pathogenesis of RA is not completely clear, but many studies have shown that TLRs and NF-κB inflammatory signaling pathways play an important role in the occurrence and development of RA. Other studies have shown that Chinese medicinal can affect TLRs, MyD88 and NF-κB signaling pathways, and play a role in regulating immunity and cytokines. Therefore, this study intends to analyze TLR4/MyD88/NF-κB signaling pathway in the occurrence and development of RA, and the research status and mechanism were preliminarily studied on the effect of Chinese medicinal on TLR4/MyD88/NF-κB signaling pathway in treatment of RA, so as to provide more therapeutic approaches for the treatment of RA. |
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