通脉复智方治疗首发脑梗死非痴呆型血管认知功能障碍的临床研究

游毅；朱乐萍；叶果馨；刘笑迎；董子源；史静卉；王长德

文章摘要

游毅；朱乐萍；叶果馨；刘笑迎；董子源；史静卉；王长德.通脉复智方治疗首发脑梗死非痴呆型血管认知功能障碍的临床研究[J].中医药信息,2024,41(3):56-61

通脉复智方治疗首发脑梗死非痴呆型血管认知功能障碍的临床研究

Clinical Study on Tongmai Fuzhi Formula in the Treatment of Vascular Cognitive Impairment with No Dementia in First Episode Cerebral Infarction Patients

投稿时间：2023-07-19 录用日期：2023-08-31

DOI：10.19656/j.cnki.1002-2406.20240309

中文关键词: 缺血性卒中非痴呆型血管认知功能障碍 P300

英文关键词: Ischemic stroke Vascular cognitive impairment with no dementia P300

基金项目:上海市卫生健康委员会科研课题（202040408）；上海市虹口区中医药科研课题（HKQ-ZYY-2020-18）；上海市中西医结合医院首届骨干青年医师培养计划（RCPY0032）；上海中医药大学科技发展基金（23KFKP09）

作者	单位
游毅；朱乐萍；叶果馨；刘笑迎；董子源；史静卉；王长德

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中文摘要:

目的：观察通脉复智方早期干预首发脑梗死非痴呆型血管认知功能障碍患者（VCIND）的临床疗效。方法：选取符合纳入标准的首发脑梗死VCIND患者68例，采用信封法随机分为治疗组和对照组，每组34例。两组均给予脑梗死常规治疗，治疗组在常规治疗基础上口服通脉复智方颗粒治疗，对照组在常规治疗基础上口服安慰剂，连续治疗30 d。比较两组患者治疗前后P300电位的潜伏期与振幅、MoCA量表、MMSE量表以及中医证候评分的变化情况。结果：与治疗前相比，两组治疗后MoCA量表、MMSE量表、P300振幅较治疗前均升高（P <0.05），中医证候评分、P300潜伏期较治疗前均降低（P <0.05），且治疗组上述指标明显优于对照组（P <0.05）；治疗组中医证候有效率为88.24%(30/34)，优于对照组的52.94(18/34)，差异具有统计学意义（P <0.05）；治疗组MoCA量表评分有效率为88.24%(30/34)，优于对照组的50%(17/34)，差异具有统计学意义（P <0.05）。结论：通脉复智方能有效改善首发脑梗死VCIND，对首发脑梗死认知功能有早期干预作用。

英文摘要:

Objective： To evaluate the effect of Tongmai Fuzhi formula （TFF） on early intervention of vascular cognitive impairment with no dementia （VCIND） in first episode ischemic stroke. Methods： Sixty - eight patients with first episode cerebral infarction VCIND who met the inclusion criteria were randomly divided into treatment group and control group by envelope method， with 34 patients in each group. Both groups were given routine treatment. The treatment group was added with TFF granule orally， while the control group was added with oral placebo， and both groups were treated for 30 days. The latent period and amplitude of P300 potential，MoCA scale， MMSE scale and TCM syndrome score were compared between the two groups before and after treatment. Results： After treatment， MoCA scale， MMSE scale and P300 amplitude increased in both groups （P < 0.05）， TCM syndrome score and P300 latency decreased （P < 0.05）， and the above indexes in the treatment group were significantly better than those in the control group （P < 0.05）. The effective rate of TCM syndrome in the treatment group was 88.24% （30/34）， which was better than that in the control group （52.94% （18/34）， and the difference was statistically significant （P < 0.05）. The effective rate of MoCA scale score in the treatment group was 88.24% （30/34）， which was better than that in the control group （50% （17/34）， and the difference was statistically significant （P < 0.05）. Conclusion： Tongmai Fuzhi formula can significantly improve VCIND in first episode ischemic stroke.

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