| 谢雅贞；刘海红.健脾祛湿解毒方治疗宫颈高危型HPV感染的临床疗效[J].中医药信息,2024,41(3):47-51 |
| 健脾祛湿解毒方治疗宫颈高危型HPV感染的临床疗效 |
| Clinical Efficacy of Jianpi Qushi Jiedu Formula in Treating High Risk HPV Infection of the Cervix |
| 投稿时间：2023-07-26 录用日期：2023-10-19 |
| DOI：10.19656/j.cnki.1002-2406.20240307 |
| 中文关键词: 宫颈高危型人乳头瘤病毒感染 健脾祛湿解毒方 治未病 湿 毒 虚 |
| 英文关键词: Cervical HR - HPV infection Jianpi Qushi Jiedu Formula Treating disease before its onset Dampness Toxin Deficiency |
| 基金项目:苏州市卫生青年骨干人才项目(Qngg2021041)；南通市卫健委课题(QA2019019)；南通市科技计划项目(MSZ20200)； |
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| 中文摘要: |
| 目的：观察健脾祛湿解毒方治疗宫颈高危型人乳头瘤病毒（HR-HPV）感染的临床疗效。方法：选取符合纳入标准的68例脾虚湿热型宫颈HR-HPV感染患者，依据随机数字表随机分为观察组和对照组，每组各34例。对照组给予重组人干扰素α2b阴道泡腾片治疗，观察组在对照组用药的基础上口服健脾祛湿解毒方，3个月为1个疗程，共治疗2个疗程。比较两组HR-HPV转阴率、临床有效率以及治疗前后中医证候积分变化情况。结果：观察组HR-HPV转阴23例，对照组HR-HPV转阴14例，观察组HR-HPV转阴率显著高于对照组（P <0.05）。治疗后，两组中医证候积分均较治疗前降低，且观察组明显低于对照组（P <0.01）。观察组总有效率91.18%(31/34)，对照组总有效率70.59%(24/34)，观察组明显优于对照组（P <0.05）。结论：健脾祛湿解毒方联合重组人干扰素α2b阴道泡腾片能明显改善脾虚湿热型宫颈高危HR-HPV感染患者的中医临床证候，有效清除持续感染的HR-HPV，临床疗效较好。 |
| 英文摘要: |
| Objective： To observe the clinical efficacy of Jianpi Qushi Jiedu Formula （JQJF） in the treatment of high - risk human papillomavirus （HR - HPV） infection in the cervix. Methods： Sixty-eight patients with cervical HR-HPV infection with splenic dampness-heat type meeting the inclusion criteria were selected and randomly divided into observation group and control group according to random number table， with 34 cases in each group. The control group was treated with recombinant human interferon α2b vaginal effervescent tablets， and the observation group was treated with the same in addition to oral JQJF， with 1 course of treatment for 3 months and 2 courses in total. The negative conversion rate of HR-HPV， clinical effective rate and TCM syndrome score before and after treatment were compared between the two groups. Results： There were 23 cases of HR-HPV negative transformation in the observation group and 14 cases in the control group.The rate of HR-HPV negative transformation in the observation group was significantly higher than that in the control group （P < 0.05）. After treatment， the TCM syndrome scores of both groups were lower than before treatment， and they were lower in the observation group than in the control group （P < 0.01）. The total effective rate of the observation group was 91.18% （31/34）， and that of the control group was 70.59% （24/34）， and the effective rate in the observation group was superior to that of the control group （P < 0.05）.Conclusion： Jianpi Qushi Jiedu Formula combined with recombinant human interferon α2b vaginal effervescent tablets can significantly improve the traditional Chinese medicine clinical symptoms of high - risk cervical HPV infection patients with spleen deficiency and dampness heat type， effectively eliminate persistent high - risk HPV infection and have good clinical efficacy. |
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