张世豪;那叶馨;东娇娇;胡建华;薛金浩;高诗雯;杨柳.牛膝盐炙工艺研究[J].中医药信息,2024,41(3):9-17 |
牛膝盐炙工艺研究 |
Stir-Baking with Salt Technique of Achyranthis Bidentatae Radix |
投稿时间:2023-09-21 录用日期:2023-10-19 |
DOI:10.19656/j.cnki.1002-2406.20240302 |
中文关键词: 牛膝 Box-Behnken响应面法 盐炙 有效成分 超高效液相色谱串联质谱 |
英文关键词: Achyranthis Bidentatae Radix Box-Behnken design-response surface methodology Stir-baking with salt Effective components Ultra high performance liquid chromatography tandem mass spectrometry |
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目);黑龙江省自然科学基金项目(LH2021H097);国家自然科学基金配套项目(2018PT02);黑龙江省青年岐黄学者培养项目;黑龙江省头雁创新团队计划;全国名老中医药专家传承工作室建设项目(NO. (2022) No. 75);第七批全国老中医药专家学术经验继承项目(NO. (2022) No. 76);黑龙江中医药大学研究生创新基金(2023yjscx034) |
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中文摘要: |
目的:探究牛膝最佳盐炙工艺。方法:采用超高效液相色谱串联质谱技术,以牛膝补肾壮骨的5种有效成分——β-蜕皮甾酮、25R-牛膝甾酮、25S-牛膝甾酮、人参皂苷R0及竹节参皂苷Ⅳa为评价指标,采用单因素和Box-Behnken设计方法,选择加盐量、炒制温度和炒制时间为考察因素,优化牛膝的盐炙工艺。结果:牛膝盐炙最佳工艺为2%加盐量,炒制温度100℃,炒制时间20 min。结论:所得牛膝盐炙工艺稳定可靠,有利于提高牛膝盐炙品的质量均一性。 |
英文摘要: |
Objective: To explore the best stir-baking with salt of Achyranthis Bidentatae Radix. Methods:In order to optimize stir-baking with salt of Achyranthis Bidentatae Radix, the technique of ultra high performance liquid chromatography tandem mass spectrometry was adopted; five effective ingredients for tonifying kidney and strengthening bone of Achyranthis Bidentatae Radix,β-Ecdysterone,25R Achyranthes,25S Achyranthes, Ginsenoside R0, and Bamboo Joint Ginsenoside Iva, were taken as evaluation indicators;single factor and Box Behnken design methods was employed; and the amount of salt added, frying temperature, and frying time were the factors to be investigated. Results: The best technique of stir-baking with salt of Achyranthis Bidentatae Radix was that the amount of salt is 2%, stirring temperature 100 °C,stirring time 20 min. Conclusion: The ingredients of stir-baking with salt of Achyranthis Bidentatae Radix are stable and reliable, which is beneficial to the quality uniformity of Achyranthis Bidentatae Radix processed with salt. |
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