| Oxidative stress is one of the important mechanisms leading to premature ovarian insufficiency(POI). Studies have found that traditional Chinese medicine(TCM) can effectively improve the antioxidant capacity of POI and reduce oxidative stress. This paper reviewed the literature on the mechanism of oxidative stress treatment of POI by TCM in recent years, and found that the main TCM treatment methods were Chinese medicine monomer extract, single Chinese medicinal, Chinese medicine formulae, Chinese patent medicine, acupuncture and combination of acupuncture and medicine. The monomers include ginsenoside Rg1, ginsenoside Rg3, hypericin, lycium barbarum polysaccharide and allantoin. Currently, only pearls have been found to be associated with POI oxidative stress in single Chinese medicinal. Chinese herbal medicine formulae include Yulin Zhu, Bushen Huoxue decoction, Chinese Angelica Blood-Supplementing decoction, Erxian decoction, as well as clinical experience of Chinese medicine formulae such as Huchao drink, Bushen Culuan formula, and Zigui Yichong formula. Chinese patent medicines include Liuwei Dihuang pill, Nongsuo Dangguiwan and Bushen Yangjing granules. Acupuncture and moxibustion mainly involves conventional acupuncture, electroacupuncture, warm acupuncture combined with moxibustion, and moxibustion, as well as the acupuncture of needle insertion from Zhibian(BL54) to Shuidao(ST28). The commonly used acupoints are Guanyuan(CV4), Qihai(CV6), Shenshu(BL23), Zusanli(ST36), etc. Chinese medicine intervention in POI can resist ovarian oxidative stress damage by affecting mitochondrial activity in ovarian granulosa cells, influencing molecules involved in oxidative stress mechanisms, and regulating oxidative stress-related signaling pathways, achieving the goal of restoring ovarian function.Oxidative stress is one of the important mechanisms leading to premature ovarian insufficiency(POI). Studies have found that traditional Chinese medicine(TCM) can effectively improve the antioxidant capacity of POI and reduce oxidative stress. This paper reviewed the literature on the mechanism of oxidative stress treatment of POI by TCM in recent years, and found that the main TCM treatment methods were Chinese medicine monomer extract, single Chinese medicinal, Chinese medicine formulae, Chinese patent medicine, acupuncture and combination of acupuncture and medicine. The monomers include ginsenoside Rg1, ginsenoside Rg3, hypericin, lycium barbarum polysaccharide and allantoin. Currently, only pearls have been found to be associated with POI oxidative stress in single Chinese medicinal. Chinese herbal medicine formulae include Yulin Zhu, Bushen Huoxue decoction, Chinese Angelica Blood-Supplementing decoction, Erxian decoction, as well as clinical experience of Chinese medicine formulae such as Huchao drink, Bushen Culuan formula, and Zigui Yichong formula. Chinese patent medicines include Liuwei Dihuang pill, Nongsuo Dangguiwan and Bushen Yangjing granules. Acupuncture and moxibustion mainly involves conventional acupuncture, electroacupuncture, warm acupuncture combined with moxibustion, and moxibustion, as well as the acupuncture of needle insertion from Zhibian(BL54) to Shuidao(ST28). The commonly used acupoints are Guanyuan(CV4), Qihai(CV6), Shenshu(BL23), Zusanli(ST36), etc. Chinese medicine intervention in POI can resist ovarian oxidative stress damage by affecting mitochondrial activity in ovarian granulosa cells, influencing molecules involved in oxidative stress mechanisms, and regulating oxidative stress-related signaling pathways, achieving the goal of restoring ovarian function. |
