| 路晓培；丁康；谭妍妍.基于线粒体功能障碍探讨中医药防治炎症性肠病的研究进展[J].中医药信息,2024,41(3):77-84 |
| 基于线粒体功能障碍探讨中医药防治炎症性肠病的研究进展 |
| Research Progress of Traditional Chinese Medicine Prevention and Treatment of Inflammatory Bowel Disease Based on Mitochondrial Dysfunction |
| 投稿时间：2023-10-26 录用日期：2023-11-25 |
| DOI：10.19656/j.cnki.1002-2406.20240313 |
| 中文关键词: 线粒体 功能障碍 炎症性肠病 研究进展 |
| 英文关键词: Mitochondria Dysfunction Inflammatory bowel disease Research progression |
| 基金项目:2023年江苏省研究生实践创新计划（SJCX23-0933） 2022年江苏省基础研究计划自然科学基金（BK20221178） 宿迁市科技计划项目（自然科学基金）（K202144） 2020年江苏省中医药科技发展计划一般项目（YB2020029） |
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| 中文摘要: |
| 炎症性肠病（IBD）是一组以慢性肠道炎症为主要特征的全球性疾病，包括克罗恩病（CD）和溃疡性结肠炎（UC），目前病因和发病机制尚不完全清楚。线粒体是细胞中的重要器官，研究发现，线粒体膜电位下降、腺嘌呤核苷三磷酸（ATP）产生减少、氧化应激加剧等现象可能促使免疫系统的异常激活，引起肠道黏膜屏障的受损，导致IBD的发生，并加速炎症进展。中药含有多种生物活性成分，具有修复线粒体功能、抑制炎症反应的潜力。因此本文基于线粒体功能对中医药防治炎症性肠病进行总结梳理，发现中医药对线粒体具有缓解氧化应激、调控线粒体自噬等作用，从而发挥抗炎、抗氧化、减轻肠黏膜损伤、延缓病情的作用，且中医药调控线粒体DNA(mtDNA)突变涉及到的炎-癌转化机制是当前的研究热点。 |
| 英文摘要: |
| Inflammatory bowel disease (IBD) is a group of global diseases characterized by chronic intestinal inflammation, including Crohn's disease (CD) and ulcerative colitis (UC), and its etiology and pathogenesis are still not fully clear. Mitochondria are important organelles in cells. Studies have found that the decrease of mitochondrial membrane potential, the decrease of adenine nucleoside triphosphate (ATP) production, and the intensification of oxidative stress may promote the abnormal activation of the immune system, cause damage to the intestinal mucosal barrier, lead to the occurrence of IBD, and accelerate the progression of inflammation.Traditional Chinese medicine contains a variety of bioactive ingredients, which have the potential to repair mitochondrial function and inhibit inflammatory reactions. This article summarizes and sorts out the prevention and treatment of inflammatory bowel disease using traditional Chinese medicine based on mitochondrial function. It is found that traditional Chinese medicine has the functions of alleviating oxidative stress and regulating autophagy on mitochondria, thereby exerting anti-inflammatory, antioxidant, reducing intestinal mucosal damage, and delaying disease progression. In addition, the mechanism of inflammation-cancer transformation involved in the regulation of mitochondrial DNA (mt DNA) mutation by traditional Chinese medicine is a current research focus. |
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