| 沈鑫玲；彭海燕.宏观调态结合微观打靶辨治结直肠癌肝转移[J].中医药信息,2024,41(3):62-66 |
| 宏观调态结合微观打靶辨治结直肠癌肝转移 |
| Differentiation and Treatment of Liver Metastases of Colorectal Cancer by Macroscopic State－Regulation and Microscopic Target－Shooting |
| 投稿时间：2023-10-31 录用日期：2023-11-25 |
| DOI：10.19656/j.cnki.1002-2406.20240310 |
| 中文关键词: 结直肠癌（肠癌） 肝转移 中医药 态靶结合 |
| 英文关键词: Colorectal cancer Liver metastasis Traditional Chinese medicine Combination of state and target |
| 基金项目:江苏省自然科学基金项目（BK20201400）；江苏高校优势学科建设工程资助项目（苏政办发[2018]87号）；国家中医药管理局全国名中医刘沈林工作室（国中医药办人教函〔2018〕119号） |
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| 中文摘要: |
| 结直肠癌发病率高，伴发肝转移是导致患者死亡的重要因素，结合中医药治疗能有效降低结直肠癌肝转移的发生率、减轻患者的临床症状，提高生活质量、延长生存期“。态靶结合”理论的辨证组方思想是将中医传统辨证思维与现代医学科技成果结合，将宏观“调态”和微观“打靶”有机结合。本文在“态靶结合”辨治理论的指导下，从宏观上辨别早期态、中期态和晚期态，根据不同“态”确立针对性的调治法则，同时在微观上辨病靶、症靶及标靶，依此选定靶方并精准结合辨靶用药，通过“态靶结合”、标本同治，构建结直肠癌肝转移中西医结合辨治新模式，可显著改善患者预后。 |
| 英文摘要: |
| The incidence of colorectal cancer is high and liver metastasis is an important factor leading to death of patients. Western medicine treatment combined with traditional Chinese medicine （TCM） can effectively reduce the incidence of liver metastasis of colorectal cancer， reduce the clinical symptoms of patients， improve the quality of life， and prolong the survival period. The syndrome differentiation and formula formation idea of the “combination of state and target” theory is to combine TCM dialectical thinking with modern scientific and technological achievements. This idea organically combines the regulating the disease stage macroscopically and shooting the target microscopically. In this paper， under the guidance of the treatment theory of "combination of state and target"， the early state， middle state and late state are distinguished from a macroscopic perspective， and the targeted regulation and treatment rules are established according to different "states". At the same time， the disease target， the symptom target and label target are identified microscopically， according to which the target is selected and the drug is accurately combined with the target identification. Through the “combination of state and target” and simultaneous treatment of root and superficiality， a new model of integrated traditional Chinese and Western medicine diagnosis and treatment for liver metastasis of colorectal cancer can be constructed， which can significantly improve the prognosis of patients. |
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