| 王嘉昊；代茜；郭宁；梁一凡；曾璇；覃湘；赖淑贤；戴红芳.基于肠道菌群探讨从脾胃论治慢性疲劳综合征[J].中医药信息,2024,41(6):35-40 |
| 基于肠道菌群探讨从脾胃论治慢性疲劳综合征 |
| Exploring the Chronic Fatigue Syndrome from Spleen-Stomach Theory Based on Intestinal Flora |
| 投稿时间：2023-11-29 录用日期：2023-12-19 |
| DOI：10.19656/j.cnki.1002-2406.20240606 |
| 中文关键词: 肠道菌群 慢性疲劳综合征 脾胃学说 |
| 英文关键词: Intestinal flora Chronic fatigue syndrome Theory of spleen and stomach |
| 基金项目:广东省中医药局科研项目;温阳健脾法调控阳虚质疲劳型亚健康肠道菌群的研究 |
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| 中文摘要: |
| 肠道菌群可通过免疫系统、精神心理、神经内分泌系统等多种途径参与慢性疲劳综合征的起病过程。中医学认为，慢性疲劳综合征病位在脾，以脾胃亏虚为基本病机，治疗宜健脾益胃，肠道菌群与脾土相通，肠道菌群是健脾类药物的重要作用靶点。健脾类药物可通过调节肠道菌群，改善肠道紊乱状态，进而调和脾胃，改善慢性疲劳综合征患者的症状。本文着眼于探究脾与肠道菌群、慢性疲劳综合征三者的联系，以期通过肠道微生物来诠释从脾胃论治慢性疲劳综合征的生物机制，进一步明确中医药治疗慢性疲劳综合征的作用机理，发现肠道菌群可影响慢性疲劳综合征的发生和进展，肠道菌群协助消化功能与脾主运化相应、辅助参与人体免疫系统的功能与脾为之卫相应、调节精神心理的功能合乎脾意、与脾胃功能失和症状相似，运用健脾类药物治疗脾胃失调为代表的调和脾胃法能有效改善肠道菌群的生态，对CFS起到更好的治疗效果，临证时应注意健脾和胃以助运化、调畅升降以助气机。 |
| 英文摘要: |
| Modern research has found that intestinal flora can be involved in the process of chronic fatigue syndrome through the immune system,mental and psychological,neuroendocrine system and other channels.Chronic fatigue syndrome is located in the spleen,with deficiency of the spleen and stomach as the basic pathogenesis,and the treatment is to strengthen the spleen and stomach. Chinese medicine believes that the intestinal flora is connected to the spleen and the earth,and the intestinal flora is an important target for spleen-enhancing drugs. By regulating the intestinal flora,spleen-enhancing drugs can improve intestinal disorders,thereby harmonizing the spleen and stomach and improving the symptoms of patients with chronic fatigue syndrome. In this paper,we focus on the connection between spleen,intestinal flora and chronic fatigue syndrome,in order to interpret the biological mechanism of treating chronic fatigue syndrome from the viewpoint of spleen and stomach through the intestinal microorganisms,to further enrich the scientific connotation of the treatment of chronic fatigue syndrome by traditional Chinese medicine,and to provide a new way of thinking for the treatment of chronic fatigue syndrome. It has been found that the gut microbiota can affect the occurrence and progression of chronic fatigue syndrome. The gut microbiota assists in digestive function and corresponds to the spleen's main movement, assists in participating in the body's immune system function and corresponds to the spleen's health, regulates mental and psychological functions in accordance with the spleen's will, and is similar to the symptoms of spleen and stomach dysfunction. The use of spleen tonifying drugs to treat spleen and stomach disorders, represented by the spleen and stomach harmony method, can effectively improve the ecology of the gut microbiota and have a better therapeutic effect on CFS, During clinical practice, attention should be paid to strengthening the spleen and stomach to aid in transportation and digestion, and regulating the smooth rise and fall to aid in qi circulation. |
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