| 李敏;刘芳媛;丁丹妮;韩凤娟.淫羊藿活性成分抗卵巢癌作用机制研究进展[J].中医药信息,2024,41(3):71-76 |
| 淫羊藿活性成分抗卵巢癌作用机制研究进展 |
| Research Progress on Anti－Ovarian Cancer Mechanism of Active Components of Herba Epimedii： A Review |
| 投稿时间：2023-12-26 录用日期：2024-01-23 |
| DOI：10.19656/j.cnki.1002-2406.20240312 |
| 中文关键词: 淫羊藿苷 淫羊藿素 淫羊藿次苷II 卵巢癌 作用机制 |
| 英文关键词: Icariin Icaritin Icariside II Ovarian cancer Mechanism |
| 基金项目: |
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| 中文摘要: |
| 卵巢癌是女性生殖系统三大癌症之一，其病死率位居妇科恶性肿瘤之首。淫羊藿具有补肾阳、强筋骨、祛风湿的功效，临床常用于生殖系统疾病的治疗。本文通过综述国内外相关文献，发现淫羊藿主要活性成分淫羊藿苷、淫羊藿素和淫羊藿次苷Ⅱ，主要从促进细胞凋亡、影响细胞的侵袭和转移、阻滞细胞周期、诱导细胞自噬、促进细胞焦亡等5个方面发挥抗卵巢癌作用，可见淫羊藿可以通过多靶点、多途径治疗卵巢癌。 |
| 英文摘要: |
| Ovarian cancer is one of the three major cancers of the female reproductive system， and its mortality rate ranks first among gynecological malignant tumors. Herba epimedii has the effect of tonifying kidney yang， strengthening sinew and bone， and dispelling wind and dampness， and is often used in the treatment of reproductive system diseases. This article reviews relevant literature at home and abroad and finds that the main active ingredients of Herba epimedii are icariin， icaritin， and icariside II. This medicinal mainly exerts anti ovarian cancer effects from five aspects： promoting cell apoptosis， affecting cell invasion and metastasis， blocking cell cycle， inducing cell autophagy， and promoting cell pyroptosis. It can be seen that the herb can treat ovarian cancer through multiple targets and pathways |
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