| 张晓娟；左冬冬；于孙婉琪.钩藤化学成分和药理作用研究进展[J].中医药信息,2024,41(2):81-86 |
| 钩藤化学成分和药理作用研究进展 |
| esearch Progress on the Chemical Components and Pharmacological Effects of Gambir Plant Nod |
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| DOI：10.19656/j.cnki.1002-2406.20240214 |
| 中文关键词: 钩藤 化学成分 药理作用 |
| 英文关键词: Gambir plant nod Chemical composition Pharmacological action |
| 基金项目: |
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| 摘要点击次数: 197 |
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| 中文摘要: |
| 钩藤始载于《名医别录》，应用历史悠久。本文查阅钩藤化学成分和药理作用的相关研究文献，发现钩藤主要含有生物碱类、三萜类、酚类、甾醇类、黄酮类、醌类、香豆素类和木脂素类等成分，具有降压、抗氧化应激、抗神经细胞凋亡、调节炎症因子及其相关通路、降脂、抗脑缺血再灌注损伤、抗纤维化、抗抑郁、抗癌和调整肠道菌群等作用，主要作用于心血管和中枢神经系统，通过调节RhoA/ROCK1、ERK/MAPK、p38MAPK/MAPK、JNK/MAPK、Akt/eNOS、PI3K/Akt、ERK1/2、p27Kip1、PI3K/Akt/GSK－3β、Src/STAT3和HIF－1α/EMT信号通路，发挥治疗高血压、阿尔茨海默病、帕金森、肺纤维化等疾病的作用。 |
| 英文摘要: |
| Gambir plant nod was first recorded in the Records of Famous Doctors and has a long history of application. This article reviews relevant research literature on the chemical components and pharmacological effects of Uncaria lobata， and finds that Uncaria lobata mainly contains alkaloids， triterpenes， phenols，sterols， flavonoids， quinones， coumarins， and lignans. It has antihypertensive， antioxidant stress， anti neuronal apoptosis， regulation of inflammatory factors and related pathways， lipid－lowering， anti cerebral ischemia－reperfusion injury， anti fibrosis， anti depression， anti－cancer， and adjustment of gut microbiota effects. They mainly act on the cardiovascular and central nervous systems， regulating RhoA/ROCK1， ERK/MAPK， p38MAPK/MAPK， JNK/MAPK， Akt/eNOS， PI3K/Akt， ERK1/2， p27Kip1， PI3K/Akt/GSK－3β，Src/STAT3 and HIF－1α/The EMT signaling pathway， and play a role in treating diseases such as hypertension， Alzheimer's disease， Parkinson's disease， and pulmonary fibrosis. |
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