| 梁思家,徐闯,徐京育.柴桂剂治疗慢性心衰伴焦虑状态的临床观察[J].中医药信息,0,(): |
| 柴桂剂治疗慢性心衰伴焦虑状态的临床观察 |
| Clinical observation of Chaigui in the treatment of chronic heart failure with anxiety |
| 投稿时间：2021-09-28 录用日期：2021-10-03 |
| DOI： |
| 中文关键词: 慢性心力衰竭 焦虑状态 临床观察 |
| 英文关键词: chronic heart failure anxiety state clinical observation |
| 基金项目:李延全国名中医传承工作室 |
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| 摘要点击次数: 587 |
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| 中文摘要: |
| 目的：探讨应用李延教授临床经验柴桂剂治疗慢性心衰伴焦虑状态的临床疗效。方法：选取2019年9月—2021年6月期间确诊慢性心力衰竭伴焦虑状态的患者62例，按照随机数字表法随机分为2组。对照组（n=31）予慢性心衰常规西医治疗，观察组在对照组基础上予以经验方柴桂剂治疗，疗程为4周。比较两组患者治疗前后中医证候积分、心功能分级、氨基末端脑钠肽前体（NT-proBNP）、左室射血分数（LVEF）、汉密尔顿焦虑状态量表（HAMA）及明尼苏达心力衰竭生活质量量表（MLHFQ），并对临床疗效进行评估。结果：观察组心功能疗效、焦虑疗效总有效率均高于对照组（p<0.05)；观察组治疗后中医证候积分、HAMA量表积分、MLHFQ评分均低于对照组（p<0.05)；两组治疗后LVEF未见明显差异（p>0.05)；观察组治疗后NT-proBNP水平明显低于对照组（p<0.01)。结论：柴桂剂治疗慢性心衰伴焦虑状态患者，能提高临床疗效，明显改善患者的心衰症状和焦虑状态，显著降低NT－proBNP水平，提高患者的生活质量，对心衰和焦虑均疗效显著。 |
| 英文摘要: |
| Objective: To explore the clinical efficacy of Chaigui Decoction in the treatment of chronic heart failure with anxiety state. Methods: Sixty-two patients with chronic heart failure and anxiety diagnosed from September 2019 to June 2021 were randomly divided into two groups according to the random number table. The control group (n = 31) was treated with conventional western medicine for chronic heart failure. The observation group was treated with Jieyu Ning Xin Fang on the basis of observation. The course of treatment was 4 weeks. TCM score, cardiac functional classification, N-terminal pro-brain natriuretic peptide (NT-proBNP), score (LVEF), Hamilton Anxiety Rating Scale (HAMA) and Minnesota Living with Heart Failure Scale (MLHFQ) were compared between the two groups before and after treatment, and the clinical efficacy was evaluated. Results: The curative effect of cardiac function and the total effective rate of anxiety in the observation group were higher than those in the control group (p < 0.05); the TCM score, HAMA scale score and MLHFQ score in the observation group were lower than those in the control group after treatment (p < 0.05); there was no significant difference in LVEF between the two groups after treatment (p > 0.05); the NT-proBNP level in the observation group was significantly lower than that in the control group after treatment (p < 0.01). Conclusion: Professor Li Yan ' s Experience Prescription Chaigui in Treatment Chronic Heart Failure and Anxiety can improve the clinical efficacy, significantly improve the symptoms and anxiety of patients with heart failure, significantly reduce the level of NT-proBNP, improve the quality of life of patients, with significant effect on heart failure and anxiety. |
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