| 王俏，张真真，万贵平.基于氧化应激探讨中医药治疗子宫内膜异位症的作用机制[J].中医药信息,2023,40(3):28-36 |
| 基于氧化应激探讨中医药治疗子宫内膜异位症的作用机制 |
| Research progress of treating EMT with TCM Therapies Based on Oxidative Stress |
| 投稿时间：2022-07-08 录用日期：2022-07-19 |
| DOI： |
| 中文关键词: 子宫内膜异位症 氧化应激 中医药 抗氧化剂 |
| 英文关键词: Endometriosis Oxidative Stress Chinese herbal medicine antioxygen |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 子宫内膜异位症（EMT）是临床常见疾病，发病机制尚不明确，氧化应激可能是EMT的发病机制之一。中医药抗氧化药物可多靶点、多途径发挥疗效，且安全有效副作用小，是西医靶向药的良好替代和补充。本文通过归纳分析中医药抗氧化治疗子宫内膜异位症的临床和基础实验研究发现中医药抗氧化疗法可以有效缩小病灶体积、抑制异位内膜的黏附、侵袭和血管新生，并且通过调节激素水平以及提高机体免疫力遏制EMT的疾病进展。同时还可明显改善EMT相关盆腔痛、不孕等临床伴随症状，有效延缓EMT恶化。因此中医药抗氧化疗法是一种既能抑制子宫内膜异位症病变进展，又能缓解子宫内膜异位症相关伴随症状的潜力疗法。 |
| 英文摘要: |
| Endometriosis (Endometriosis，EMS) is a common clinical disease, and its pathogenesis is still unclear. Oxidative stress is one of the possible pathogenesis of EMS.Antioxidant drugs of traditional Chinese medicine can exert curative effects in multiple targets and ways, and are safe and effective with little side effects, so they are good substitutes and supplements for targeted drugs of western medicine.In this paper, the clinical and basic experimental studies on the treatment of endometriosis with traditional Chinese medicine (TCM) antioxidant therapy were summarized and analyzed. It was found that TCM antioxidant therapy could effectively reduce the lesion volume, inhibit the adhesion, invasion and angiogenesis of ectopic endometrium, and curb the disease progress of EMS by regulating hormone levels and improving immunity.At the same time, it can obviously improve the clinical accompanying symptoms such as pelvic pain and infertility related to EMS, and effectively delay the deterioration of EMS.Therefore, anti-oxidation therapy of traditional Chinese medicine is a potential therapy that can not only inhibit the progress of endometriosis, but also alleviate the associated symptoms of endometriosis, so as to provide new ideas for clinical treatment of endometriosis. |
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