| Microglia-mediated inflammatory responses play an important role in the pathogenesis of ischemic stroke(IS). Through the organization and analysis of relevant literature in the past three years, it was found that microglia play a dual role in the pathological development, progression, and outcome of IS. M1-type microglia have pro-inflammatory effects, while M2-type microglia exert anti-inflammatory effects. Traditional Chinese medicine has the characteristics of multiple targets, multiple pathways, and bidirectional regulation. Its active components(such as terpenoids, flavonoids, and coumarins) can promote the polarization of microglia from M1 type to M2 type by regulating JAK2/STAT3/Drp, NF-κB/Nrf2, JAK/STAT3, PI3K/Akt and other pathways, reduce the release of pro-inflammatory mediators such as IL-1β, NO and TNF-α, and increase the expression of anti-inflammatory mediators such as IL-10, TGF-β and Arg-1. Therefore, traditional Chinese medicine can reduce nerve function defect, reduce neuroinflammatory reaction, alleviate brain injury, and play a neuroprotective role. It can provide reference for the prevention and treatment of IS and the development of new drugs for IS, and can be expected to become an effective strategy for the treatment of IS. |
