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| 旋金降逆汤对反流性食管炎肝胃郁热证患者焦虑、抑郁影响的临床研究 |
| Clinical Research on the effects of Xuanjinjiangni Decoction on anxiety and depression in patients with Reflux Esophagitis with the type of Heat Stagnation of Liver and Stomach |
| 投稿时间：2019-09-16 录用日期：2019-10-28 |
| DOI： |
| 中文关键词: 旋金降逆汤，反流性食管炎，肝胃郁热证，焦虑自评量表，抑郁自评量表，临床研究 |
| 英文关键词: Xuanjinjiangni Decoction, Reflux Esophagitis, Heat Stagnation of Liver and Stomach, Self-Rating Anxiety Scale, Self-Rating Depression Scale, Clinical Research. |
| 基金项目:嘉定区科委立项项目(JDKW-2016-w24);上海市“杏林新星”计划(ZY3-RCPY-2-2060)；嘉定区第二批中医脾胃病重点专科建设项目(2017-ZYZDZK-01)；嘉定区中医工作室建设项目(ZYGZS-06)第一作者：吴晓华(1966-),学士,主治医师,从事于中医药脾胃病研究；通讯作者：尚莹莹(1984-),博士,副主任医师,从事于中医药脾胃病研究。通讯地址：上海市嘉定区博乐路222号嘉定区中医医院内科医生办公室 邮编：201800 联系电话：13671707349 021-39921303 E-mail：shangyingying2001@163.com. |
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| 中文摘要: |
| 目的：观察旋金降逆汤对反流性食管炎肝胃郁热证患者焦虑、抑郁情绪的影响。方法：采用Excel软件Rand()公式产生的随机数字表,将80例观察对象随机分为两组,治疗组和对照组各40例,分别给予旋金降逆汤和奥美拉唑治疗,8周疗程结束,比较两组治疗前后临床症状、食管粘膜炎症、焦虑自评量表评分、抑郁自评量表评分。结果：1.临床疗效：治疗组临床总有效率为82.5%,对照组为57.14%,两组比较具有显著差异(P<0.05)。2.内镜疗效：治疗组食管粘膜炎症改善有效率为63.64%,对照组为65.0%,两组比较无显著差异(P>0.05)。3.焦虑自评量表评分：两组治疗后焦虑自评量表评分较治疗前明显降低,两组治疗后比较有显著差异,治疗组优于对照组(P<0.05)。4.抑郁自评量表评分：两组治疗后抑郁自评量表评分较治疗前明显降低,两组治疗后比较无显著差异(P<0.05)。结论：旋金降逆汤能够减轻反流性食管炎肝胃郁热证患者的临床症状,促进食管粘膜炎症的愈合,改善患者焦虑和抑郁情绪。 |
| 英文摘要: |
| Object: To observe the effect of Xuanjinjiangni decoction on anxiety and depression in patients with Reflux Esophagitis with the type of Heat Stagnation of Liver and Stomach. Methods: Through the random number tables generated by Rand () formula with the Excel software, 80 patients were randomly divided into treatment group and control group(n=40), respectively treated with Xuanjinjiangni decoction and omeprazole. After 8 weeks, compare the clinical sypmtoms, esophageal mucosal inflammation, and scores of self-rating anxiety scale and self-rating depression scale. Results: 1.Clinical efficacy: clinical effective rate in treatment group was 82.5% and control group was 57.14% . There was significant difference between two groups (P<0.05).2. Endoscopic efficacy: The effective rate of improvement of esophageal mucosal inflammation in treatment group was 63.64% and 65.0% in control group. There was no significant difference between two groups (P>0.05).3. Scores of self-rating anxiety scale: scores of self-rating anxiety scale of the treatment group and the control group were significantly decreased after treatment, and the treatment group was better than the control group (P<0.05).4. Scores of self-rating depression scale: the depression scale scores of the treatment group and the control group were significantly decreased after treatment, however, there was no significant difference between two groups (P<0.05).Conclusion: Xuanjinjiangyi decoction can relieve clinical symptoms, improve esophageal mucosal inflammation and the anxiety and depression in patients with reflux esophagitis with the type of heat stagnation of liver and stomach. |
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