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| 薏苡附子败酱方对痛风性关节炎(湿热痹阻证)患者疗效、关节功能、血清促炎因子影响研究陶江涛通讯作者,张敏,刘方,马玉(南阳南石医院中医科/风湿免疫科；河南 南阳 473000) |
| Effects of CoIX Seed Paste recipe on curative effect, joint function and serum proinflammatory factors in patients with gout arthritis (Damp-heat bizu syndrome) |
| 投稿时间：2020-07-18 录用日期：2020-08-03 |
| DOI： |
| 中文关键词: 痛风性关节炎 湿热痹阻证 急性期 薏苡附子败酱方 疗效 关节功能 |
| 英文关键词: |
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| 中文摘要: |
| 目的 探究薏苡附子败酱方对痛风性关节炎(湿热痹阻证)患者疗效、关节功能、血清促炎因子影响。方法 研究纳入134例痛风性关节炎(湿热痹阻证)患者,均由我院2018年4月~2020年1月收治,采取随机数字表法将患者分成两组,对照组患者(67例)均行西医常规治疗,观察组患者(67例)西医常规治疗结合薏苡附子败酱方治疗,比较两组患者临床疗效、治疗前后中医症状(关节红肿热痛、发热烦闷、活动不利、口渴便黄等)积分变化、关节恢复评分变化、血沉及血尿酸水平变化、血清促炎因子水平变化、不良反应。结果 观察组患者治疗总有效率(97.01%)高于对照组(88.06%),p＜0.05；治疗前,两组患者关节红肿热痛、发热烦闷、活动不利、口渴便黄等中医症状积分、关节疼痛及关节压痛、关节功能等关节恢复评分、血沉及血尿酸S水平、C反应蛋白(CRP)、白介素-1β(IL-1β)、肿瘤坏死因子α(TNF-α)等血清促炎因子水平比较,p＞0.05,治疗后各组患者关节红肿热痛、发热烦闷、活动不利、口渴便黄等中医症状积分、关节疼痛及关节压痛、关节功能等关节恢复评分、血沉及血尿酸S水平、CRP、IL-1β、TNF-α等指标均改善,观察组患者治疗后关节红肿热痛、发热烦闷、活动不利、口渴便黄等中医症状积分、关节疼痛及关节压痛、关节功能等关节恢复评分、血沉及血尿酸S水平、CRP、IL-1β、TNF-α等指标均优于对照组,p＜0.05；观察组治疗过程中未见不良反应(0.00%),对照组出现1例胃肠道反应(1.49%),p＞0.05。结论 薏苡附子败酱方治疗痛风性关节炎(湿热痹阻证)效果显著,患者关节恢复良好,疼痛缓解,炎症因子水平下降,无不良反应,安全性高,可深入研究。 |
| 英文摘要: |
| Objective To explore the effect, joint function and serum proinflammatory factors of Coix lachrymatory arthritis (Gout). Methods Study included 134 patients with gouty arthritis (hot and humid bizu) patients, from April 2018 to January 2020, take a random number table method divided the patients into two groups, control group (n = 67) were performed in patients with conventional western medicine treatment, the observation group (67 cases) patients with routine therapy combined with western medicine job "s-tears monkshood defeat sauce treatment, compared two groups of patients with clinical efficacy, TCM symptoms before and after the treatment (heat joint swelling pain, fever, irritancy, adverse events, thirst and yellow, etc.) change integral, joint recovery score, blood sedimentation and blood uric acid level changes, changes in serum levels of proinflammatory factor, adverse reactions.Results The total effective rate (97.01%) in the observation group was higher than that in the control group (88.06%), P < 0.05. Joint swelling, before the treatment, two groups of patients with thermal pain, fever, irritancy, adverse events, thirst and yellow wait for TCM symptoms integral, joint pain, joint tenderness and joint function joint recovery score, blood sedimentation and blood uric acid levels, c-reactive protein (CRP) and interleukin 1 beta (IL - 1 beta), tumor necrosis factor alpha (TNF alpha) serum levels of proinflammatory factor comparison, p > 0.05. Joint swelling, groups of patients after treatment thermal pain, fever, irritancy, adverse events, thirst and yellow wait for the doctor of traditional Chinese medicine symptom integral, joint pain, joint tenderness and joint function joint recovery score, blood sedimentation and blood uric acid level, CRP, IL - 1 beta and TNF alpha indexes improved, joint swelling, observation group of patients after treatment thermal pain, fever, irritancy, adverse events, thirst and yellow wait for TCM symptoms integral, joint pain, joint tenderness and joint function joint recovery score, blood sedimentation and blood uric acid level, CRP, IL - 1 beta and TNF alpha indicators are superior to control group, p < 0.05; No adverse reactions were observed during treatment in the observation group (0.00%), while gastrointestinal reactions (1.49%) were observed in the control group (p > 0.05).Conclusion Coix seed paste recipe is effective in the treatment of gout arthritis (damp-heat bizu syndrome), with good joint recovery, pain relief, inflammatory factor reduction, no adverse reactions, high safety, and may be further studied. |
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