文章摘要
延胡索的化学成分和药理作用研究进展
Research Progress on chemical constituents and pharmacological effects of Corydalis Rhizoma
投稿时间:2021-03-05  录用日期:2021-04-07
DOI:
中文关键词: 延胡索,化学成分,药理作用,研究进展
英文关键词: Corydalis Rhizoma  Chemical constituents  pharmacological effects  research progress
基金项目:
作者单位邮编
陈斯* 四川省第二中医医院 610000
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中文摘要:
      延胡索(Corydalis Rhizoma)系临床常用中药,为传统道地药材“浙八味”之一,在我国具有悠久的应用历史。本文通过系统地归纳、梳理国内外相关文献,发现延胡索含有生物碱类、甾体类、有机酸类、糖类等多类化学成分,主要活性成分为原小檗碱类生物碱,包括延胡索乙素、延胡索甲素、去氢紫堇碱等。延胡索的药理作用涉及镇痛、抗焦虑、镇静催眠、抗心肌缺血、抗脑缺血、抗胃溃疡作用、抗肿瘤、戒毒作用、增强内分泌系统功能、抗血小板聚集、抗抑郁等方面。
英文摘要:
      Corydalis Rhizoma is a commonly used Chinese medicine in clinical practice. It is one of the traditional genuine regional drug “Eight of Zhejiang Provinces” and has a long history of application in my country. In this study, by systematically summarizing and combing the relevant literature at home and abroad, it was found that Corydalis Rhizoma contained alkaloids, steroids, organic acids, carbohydrates and other chemical components. The main active components were protoberberine alkaloids, including tetrahydropalmatine, corydaline, dehydrocorydaline, etc. The pharmacological effects of Corydalis Rhizoma involve analgesia, anti-anxiety, sedative and hypnotic, anti-myocardial ischemia, anti-cerebral ischemia, anti-gastric ulcer action, anti-tumor, drug-abstinent effect, enhancement of endocrine system function, anti-platelet aggregation, and antidepressant.
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