文章摘要
自拟慢阻肺康复方治疗稳定期慢阻肺临床疗效及对患者血清炎症因子与肺功能影响观察
Clinical efficacy and effect of self-designed chronic obstructive pulmonary rehabilitation prescription on patients with stable chronic obstructive pulmonary disease (COPD) and serum inflammatory factors and pulmonary function
投稿时间：2022-12-26  录用日期：2023-02-01
DOI：
中文关键词: 稳定期慢阻肺  自拟慢阻肺康复方  沙美特罗替卡松粉吸入剂  疗效  肺功能  不良反应
英文关键词: 
基金项目:河南省科学技术厅项目（编号：LHGJ20191401）
作者单位邮编
黄浦 许昌市中心医院 461000
杨小静 许昌市中心医院 461000
朱梦琪 许昌市中心医院 461000
刘鑫 许昌市中心医院 461000
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中文摘要:
      目的 评估自拟慢阻肺康复方治疗稳定期慢阻肺临床疗效及对患者血清炎症因子与肺功能影响。方法 将我院收治的106例稳定期慢阻肺患者（2020年1月~2022年6月）纳入本次研究，以随机数字表法将其划分为西医治疗组以及中医方剂组，各53例，西医治疗组患者采取西药沙美特罗替卡松粉吸入剂治疗，中医方剂组患者给予沙美特罗替卡松粉吸入剂治疗同时结合自拟慢阻肺康复方治疗，两组患者数据观察：临床疗效、治疗前后血清白介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）水平变化情况、中医证候总积分变化、圣乔治呼吸问卷（SGRQ）总评分变化、肺功能指标变化、不良反应。结果 中医方剂组治疗效果（94.34%）优于西医治疗组（79.25%），p＜0.05；治疗前，各组患者IL-6、TNF-α、中医证候总积分、SGRQ评分、用力肺活量（FVC）及第1秒用力呼气容积（FEV1）、FEV1/ FVC等肺功能指标比较，p＞0.05，治疗后各组患者IL-6、TNF-α、中医证候总积分、SGRQ评分、用力肺活量（FVC）及第1秒用力呼气容积（FEV1）、FEV1/ FVC等肺功能指标均显著改善，而中医方剂组患者治疗后IL-6、TNF-α、中医证候总积分、SGRQ评分、FVC及FEV1、FEV1/ FVC等肺功能指标均优于西医治疗组患者，p＜0.05；西医治疗组出现1例恶心，中医方剂组出现1例心悸，p＞0.05。结论 自拟慢阻肺康复方治疗稳定期慢阻肺疗效甚佳，可较好改善患者症状、肺功能情况，安全可行。
英文摘要:
      Objective To evaluate the clinical efficacy and influence on serum inflammatory factors and lung function of patients with chronic obstructive pulmonary disease (COPD) at stable stage treated with self-designed COPD rehabilitation formula.Methods A total of 106 patients with stable COPD admitted to our hospital from January 2020 to June 2022 were included in this study. They were randomly divided into western medicine treatment group and traditional Chinese medicine prescription group, 53 cases in each group. Patients in western medicine treatment group were treated with salmeterol and fluticasone powder inhalation. Patients in traditional Chinese medicine prescription group were treated with salmeterol and fluticasone powder inhalation combined with self-designed COPD rehabilitation prescription. Data observation of the two groups: Clinical efficacy, changes of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) levels before and after treatment, changes of total score of traditional Chinese medicine syndrome, changes of total score of St. George's Respiratory Questionnaire (SGRQ), changes of pulmonary function indexes, adverse reactions.Results The therapeutic effect of Chinese medicine prescription group (94.34%) was better than that of western medicine treatment group (79.25%), p < 0.05; Before treatment, IL-6, TNF-α, total score of TCM syndrome, SGRQ score, forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/ FVC and other pulmonary function indexes were compared among groups, p > 0.05. After treatment, IL-6, TNF-α, total score of TCM syndrome, SGRQ score, forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/ FVC and other pulmonary function indexes were significantly improved in all groups. After treatment, IL-6, TNF-α, total score of TCM syndrome, SGRQ score, FVC and FEV1, FEV1/ FVC and other pulmonary function indexes in TCM prescription group were better than those in Western medicine treatment group (p < 0.05). There was 1 case of nausea in the western medicine group and 1 case of palpitation in the traditional Chinese medicine group (p > 0.05).Conclusion The self-designed COPD rehabilitation formula is effective in the treatment of stable COPD, which can better improve the symptoms and pulmonary function of patients, and is safe and feasible.
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